What to Know Ahead of Chiefs’ Season-Opener

Kickoff Details

When:

* Sunday, September 11, 2022

Time:

* 4:25 p.m. ET

Where:

* State Farm Stadium in Glendale, Arizona

TV:

* CBS

Injury Report

Chiefs wide receiver JuJu Smith-Schuster (knee) is questionable for the game.

Cardinals cornerback Antonio Hamilton (ankle) is also questionable.

Key Matchups

Chiefs passing game vs. Cardinals secondary

The Chiefs have one of the most explosive passing attacks in the NFL, led by quarterback Patrick Mahomes and a talented group of receivers.

The Cardinals secondary will be tested early and often.

Cardinals running game vs. Chiefs defense

The Cardinals have a talented running back duo in James Conner and Eno Benjamin.

The Chiefs defense will need to be stout against the run to force the Cardinals into one-dimensional.

Prediction

The Chiefs are a 6.5-point favorite over the Cardinals.

They have the more talented roster and should be able to win this game outright.